Design of a DVB-T2 simulation platform and network optimization with Simulated Annealing

The implementation of the Digital Terrestrial Television is becoming a reality in the Spanish territory. In this context, with the satellite and cable systems, this technology is one of the possible mediums for the television signal transmission. Its development is becoming crucial for the digital transition in those countries which mainly depend on the terrestrial networks for the reception of multimedia contents. However, due to the maturity of the current standard, and also to the higher requirements of the customer needing (HDTV, new contents, etc.), a revision of the current standard becomes necessary. The DVB organisation in collaboration with other entities and organisms has developed a new standard version capable to satisfy those requirements. The main objective of the project is the design and implementation of a physical layer simulation platform for the DVB-T2 standard. This simulator allows the theoretical evaluation of the new enhanced proposals, making easier a later field measurement stage and the future network deployment. The document describes the implementation of the simulation platform as well as its subsequent validation stage, including large graphical results that allow the evaluation and quantification of the improvements introduced over the current standard version (DVB-T). On the other hand, and as future investigation lines, a solution for the future DVB-T2 network deployment is performed, enhancing the coverage capacity of the current network by the use of iterative meta-heuristic techniques. Finally it has to be mentioned that this work has been performed within the context of a project called FURIA, which is a strategic research project funded by the Spanish Ministry of Industry, Tourism and Commerce

Design of a simulation platform to test next generation of terrestrial DVB

Digital Terrestrial Television Broadcasting (DTTB) is a member of our daily life routine, and nonetheless, according to new users’ necessities in the fields of communications and leisure, new challenges are coming up. Moreover, the current Standard is not able to satisfy all the potential requirements. For that reason, first of all, a review of the current Standard has been performed within this work. Then, it has been identified the needing of developing a new version of the standard, ready to support enhanced services, as for example broadcasting transmissions to moving terminals or High Definition Television (HDTV) transmissions, among others. The main objective of this project is the design and development of a physical layer simulator of the whole DVB-T standard, including both the complete transmission and reception procedures. The simulator has been developed in Matlab. A detailed description of the simulator both from a functional and an architectural point of view is included. The simulator is the base for testing any possible modifications that may be included into the DVB-T2 future standard. In fact, several proposed enhancements have already been carried out and their performance has been evaluated. Specifically, the use of higher order modulation schemes, and the corresponding modifications in all the system blocks, have been included and evaluated. Furthermore, the simulator will allow testing other enhancements as the use of more efficient encoders and interleavers, MIMO technologies, and so on. A complete set of numerical results showing the performance of the different parts of the system, are presented in order to validate the correctness of the implementation and to evaluate both the current standard performance and the proposed enhancements. This work has been performed within the context of a project called FURIA, which is a strategic research project funded by the Spanish Ministry of Industry, Tourism and Commerce. A brief description of this project and its consortium has been also included herein, together with an introduction to the current situation of the DTTB in Spain (called TDT in Spanish)

Design of a DVB-T2 simulation platform and network optimization with Simulated Annealing

The implementation of the Digital Terrestrial Television is becoming a reality in the Spanish territory. In this context, with the satellite and cable systems, this technology is one of the possible mediums for the television signal transmission. Its development is becoming crucial for the digital transition in those countries which mainly depend on the terrestrial networks for the reception of multimedia contents. However, due to the maturity of the current standard, and also to the higher requirements of the customer needing (HDTV, new contents, etc.), a revision of the current standard becomes necessary. The DVB organisation in collaboration with other entities and organisms has developed a new standard version capable to satisfy those requirements. The main objective of the project is the design and implementation of a physical layer simulation platform for the DVB-T2 standard. This simulator allows the theoretical evaluation of the new enhanced proposals, making easier a later field measurement stage and the future network deployment. The document describes the implementation of the simulation platform as well as its subsequent validation stage, including large graphical results that allow the evaluation and quantification of the improvements introduced over the current standard version (DVB-T). On the other hand, and as future investigation lines, a solution for the future DVB-T2 network deployment is performed, enhancing the coverage capacity of the current network by the use of iterative meta-heuristic techniques. Finally it has to be mentioned that this work has been performed within the context of a project called FURIA, which is a strategic research project funded by the Spanish Ministry of Industry, Tourism and Commerce

Design of a simulation platform to test next generation of terrestrial DVB

Digital Terrestrial Television Broadcasting (DTTB) is a member of our daily life routine, and nonetheless, according to new users’ necessities in the fields of communications and leisure, new challenges are coming up. Moreover, the current Standard is not able to satisfy all the potential requirements. For that reason, first of all, a review of the current Standard has been performed within this work. Then, it has been identified the needing of developing a new version of the standard, ready to support enhanced services, as for example broadcasting transmissions to moving terminals or High Definition Television (HDTV) transmissions, among others. The main objective of this project is the design and development of a physical layer simulator of the whole DVB-T standard, including both the complete transmission and reception procedures. The simulator has been developed in Matlab. A detailed description of the simulator both from a functional and an architectural point of view is included. The simulator is the base for testing any possible modifications that may be included into the DVB-T2 future standard. In fact, several proposed enhancements have already been carried out and their performance has been evaluated. Specifically, the use of higher order modulation schemes, and the corresponding modifications in all the system blocks, have been included and evaluated. Furthermore, the simulator will allow testing other enhancements as the use of more efficient encoders and interleavers, MIMO technologies, and so on. A complete set of numerical results showing the performance of the different parts of the system, are presented in order to validate the correctness of the implementation and to evaluate both the current standard performance and the proposed enhancements. This work has been performed within the context of a project called FURIA, which is a strategic research project funded by the Spanish Ministry of Industry, Tourism and Commerce. A brief description of this project and its consortium has been also included herein, together with an introduction to the current situation of the DTTB in Spain (called TDT in Spanish)

DVB-T2 network optimization with swimulated annealing

Postprint (author’s final draft

GenLab: app multiplataforma para cursos de genética

El presente trabajo ha tratado de crear una aplicación para el desarrollo y despliegue de ejercicios relacionados con el campo de la genética. Los ejercicios han sido anteriormente desarrollados por César Benito Jiménez (profesor de la Facultad de Biología de la Universidad Complutense de Madrid) mediante MIT App Inventor. Esta solución presentaba varios problemas. Añadir nuevos ejercicios suponía una dificultad para hacerlos llegar a los alumnos, qué debían descargar de nuevo la aplicación. Además, estas aplicaciones eran demasiado pesadas, al contener todas las imágenes y textos necesarios. Para integrar todas las partes de estos ejercicios ha sido necesario estudiar su lógica y generalizarla, de modo que se facilita la creación y gestión de estas. Para facilitar estas tareas se ha creado una aplicación con una arquitectura cliente-servidor. La parte de servidor está basada en Java Spring Framework y permite gestionar los distintos contenidos que se muestran al usuario final. Gracias a la parte del servidor se consigue que el profesor no necesite conocimientos de programación para poder gestionar esta aplicación, solo de genética y de navegación web. La parte de cliente es una aplicación móvil que integra las distintas funcionalidades gestionadas por el servidor para que el alumno pueda interactuar con ellas. Dicha aplicación móvil se ha construido con distintas tecnologías web como HTML5, CSS3 y JavaScript. Todo ello se ha encapsulado con Cordova para permitir que fuese una aplicación multiplataforma (Android e iOS), y así poder permitir el uso de la aplicación al mayor número de alumnos posibles

Oligodendrocyte metabolism throughout its differentiation: immunocytochemistry study and its impact in remyelination

Introduction: Oligodendrocytes (OL) role in demyelinating pathologies such as multiple sclerosis and other neurodegenerative diseases is only recently being subject of extensive research. While the genetic and molecular aspects have been thoroughly studied, their metabolism was overshadowed. In order to develop new therapies to promote remyelination of already damaged axons, we need to accurately describe how OL metabolism affects axon myelination and trophic support (1). The objective of this study is to obtain cytological evidence of the extent of both glycolytic metabolism and oxidative phosphorylation by immunocytochemistry throughout the development of OL. Methods: Oligodendroglia cells from post-natal mice cortices were obtained and cultured. A wide assortment of differentiation-stage-specific cell surface antigens, a glycolytic and an oxidative phosphorylation marker were combined in several immunofluorescences to study both metabolic pathways in each step of differentiation. Results: After analysing them under confocal microscopy and imaging software, we observed a constant upregulation of glycolytic metabolism throughout differentiation, while oxidative phosphorylation seemed to increase with differentiation to then decrease when oligodendrocytes achieved their final maturation stage. Conclusions: Therefore, oxidative phosphorylation may be crucial in the differentiation of precursors and glycolysis would thus be the preferred metabolic pathway for fully matured OL. [1] Rosko L. et al. Neuroscientist. 2019;25(4):334–43.Supported by UMA and IBIMA and funding from two ongoing projects: - ‘Modulation of oligodendrocyte metabolism via blood vessel remodelling as target to promote remyelination’ (funding by NEURATRIS). - ‘Blood vessel remodelling modulates remyelination by oligodendrocyte metabolic reprogramming’ (funding by Arsep Foundation). Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Gastrointestinal cancer: Relationship between histology and microbiota

Este trabajo fue presentado como comunicación tipo póster en el citado congreso.Objectives: Review of the published literature concerning the relationship between microbiome and gastrointestinal cancer. Methods: Present work is focused on systematic research in the most prominent biomedical databases finds relevant works in Pubmed and the library’s catalog of the University of Málaga (Jábega) of published journals in the last 5 years. Results: In this work, the mechanisms used by the microbiome to damage gastrointestinal epithelial cells and cause cancer are explained. Some of them are the dysbiosis, destruction of the mucosal barrier, chronic inflammation, damage caused by metabolites produced in the digestion and the direct attack of certain toxins to the cell’s DNA. These mechanisms adjust the immune response, by activation or inhibition using different cytokines. There is also a deeper look into several microorganisms and how they cause gastrointestinal cancer using toxins or virulence factors to activate them. Conclusions: The evidence found so far about the microbiota and gastrointestinal cancer is enough to assume the relationship between them, although there is much left to research. With these findings, it can be expected that in a near future certain microorganisms could be used for screening purposes, due to their increase in early stages of the tumor genesis and also, in a preventive way to try to eradicate them, even avoid cancer. Studies on the microbiota are hardly beginning, and results appear to be promising.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies characterizing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness

The role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: the case of the spike A222V mutation

Resumen del trabajo presentado a las II Jornadas Científicas PTI + Salud Global, celebradas los días 5 y 6 de octubre de 2022 en el Auditorio Santiago Grisolía de Valencia (España).Peer reviewe